Highway 22 is closed in both directions five miles east of Gates due to a fatal crash, according to the Oregon Department of Transportation.
The agency released a statement about the multi-vehicle wreck at 4 p.m.
The closure could be lengthy for a law enforcement investigation and reconstruction, and there is no easy detour.
Travelers should avoid the area, use an alternate route or expect long delays, according to ODOT.
Sign up for our Crime & Courts newsletter
Get the latest in local public safety news with this weekly email.