Harrisburg opened Mountain Valley Conference play with a 53-20 home loss to Glide.
The Eagles dropped to 0-4 on the season.
Sierra Briggs led the team with eight points.
Harrisburg returns to action on Saturday at Jefferson.
Estacada 61, Sweet Home 41
Sweet Home suffered its third straight loss and fell to 2-4 on the season.
The Huskies host Cascade on Friday.